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Lennox-Gastaut Syndrome Market Epidemiology & unmet need
Lennox-Gastaut Syndrome (LGS) is a severe, childhood-onset epileptic encephalopathy characterized by multiple seizure types, cognitive impairment, and frequent comorbidities. The therapeutic landscape for LGS blends antiseizure medications (ASMs), dietary therapy (e.g., ketogenic diet), neurostimulation, and surgical approaches. The market centers on unmet needs for durable seizure reduction and cognitive outcome improvement.
Epidemiology & unmet need
LGS is rare but clinically severe; onset typically between ages 1–8. Management is complex due to mixed seizure types (tonic, atonic, atypical absences) and treatment-resistant epilepsy. High rates of comorbid intellectual disability and behavioral problems necessitate multidisciplinary care and long-term support, driving demand for effective therapies and supportive services.
Treatment landscape
Approved pharmaceutical options include broad-spectrum ASMs such as valproate, lamotrigine, rufinamide, clobazam, and newer agents with indications or data in LGS (e.g., cannabidiol/Epidiolex). Non-pharmacologic options include vagus nerve stimulation (VNS), corpus callosotomy in refractory atonic seizures, and dietary therapies. Research into precision medicine, novel…
Hello! LGS sounds serious. Did you post this to spread awareness or is there anything I can help you with?